Gene interactions and pathways from curated databases and text-mining

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PTGS2 — SLC22A3

Text-mined interactions from Literome

Neil et al., Carcinogenesis 2008 : Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2 dependent mechanisms ... Moreover, stable Cox-2 expression in normal MECs stimulated their invasion, EMT and anchorage independent growth and inhibited their activation of Smad2/3 by TGF-beta
Adhim et al., Br J Cancer 2011 (Urinary Bladder Neoplasms) : In this study, we investigated the effect of Cox-2 inhibitors on reversal EMT and tumour growth inhibition in bladder cancer cells