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ABL1 — PCNA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
He et al., Apoptosis 2009
:
Moreover, deletion of a domain in c-Abl, the PIP box, disrupts its interaction with PCNA, abolishes the
PCNA induced degradation of nuclear
c-Abl , and substantially increases the nuclear c-Abl apoptotic function ... These findings indicate that
PCNA negatively
regulates the stability of
c-Abl and thereby inhibits apoptosis in the response to DNA damage
Zhao et al., PloS one 2012
(Breast Neoplasms...) :
We found that phosphorylation of
PCNA at tyrosine 211 ( Y211 )
enhanced its association with the non-receptor tyrosine kinase
c-Abl ... Targeting Y211 phosphorylation of
PCNA with a cell-permeable peptide inhibited the phosphorylation and
reduced the
PCNA-Abl interaction