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MYL2 — RHOA

Pathways - manually collected, often from reviews:

• KEGG Tight junction: RHOA → MYH1/MYH10/MYH11/MYH13/MYH14/MYH15/MYH2/MYH3/MYH4/MYH6/MYH7/MYH7B/MYH8/MYH9/MYL10/MYL12A/MYL12B/MYL2/MYL5/MYL7/MYL9/MYLPF (protein-protein, indirect effect)
  

Text-mined interactions from Literome

Sakurada et al., Circ Res 2003 : The expression of dominant negative N19RhoA suppressed Ca2+ induced Thr695 phosphorylation of the 110-kDa regulatory subunit of myosin phosphatase and phosphorylation of myosin light chain in VSM cells
Sowers et al., Am J Physiol Heart Circ Physiol 2004 (Hypertension...) : Activated RhoA and increased reactive oxygen species inhibition of PI3K/Akt signaling results in decreased endothelial cell production of nitric oxide, increased myosin light chain activation with vasoconstriction, and reduced skeletal muscle glucose transport
Sahai et al., J Cell Biol 2007 (Neoplasm Invasiveness...) : We report that Smurf1 dependent RhoA degradation in tumor cells results in the down-regulation of Rho kinase ( ROCK ) activity and myosin light chain 2 (MLC2) phosphorylation at the cell periphery
Stuart et al., J Biol Chem 2008 (Neoplasms) : We show here that activated RhoA , but not Rac1, is enriched in pseudopodia of MSV-MDCK-INV tumor cells and that Rho, Rho kinase ( ROCK ), and myosin II regulate the microtubule independent targeting of RNA to these tumor cell domains
Ramachandran et al., Invest Ophthalmol Vis Sci 2010 : Phosphorylated myosin light chain ( ppMLC ), a biochemical measure of actomyosin contraction, and activation of its upstream regulatory molecule RhoA-GTP were assessed by Western blot analysis
Takesono et al., PloS one 2010 : The myosin inhibitor blebbistatin also stabilizes MTs, indicating that RhoA/ROCK act through myosin II to destabilize MTs
Tamura et al., Biochem Biophys Res Commun 2010 : Filamentous actin and myosin-II are major determinants of cell mechanics and are tightly regulated by a small guanosine triphosphatase, RhoA , and its downstream effectors
Pagiatakis et al., J Biol Chem 2012 (MAP Kinase Signaling System) : During contraction, VSMCs modulate calcium sensitivity through RhoA/ROCK mediated inhibition of the myosin light chain phosphatase complex ( MLCP )
Wojciak-Stothard et al., Circ Res 2012 (Anoxia...) : Coordinated activation of RhoA and RhoB maximized the hypoxia induced stress fiber formation caused by RhoB/mammalian homolog of Drosophila diaphanous induced actin polymerization and RhoA/Rho kinase induced phosphorylation of myosin light chain on Ser19
Korkina et al., J Biol Chem 2013 (Neoplasm Invasiveness...) : In contrast, as expected, depletion of RhoA inhibits myosin light chain phosphorylation