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F2R — RHOA

Text-mined interactions from Literome

Greenberg et al., Biochemistry 2003 : Stimulation with 150 microM PAR activating peptides TFFLRN ( PAR1 ), SLIGKV ( PAR2 ), and AYPGKF ( PAR4 ) demonstrated that PAR1 and PAR2 mediated protease activated RhoA signaling
Jenkins et al., J Clin Invest 2006 (Pulmonary Edema...) : This effect is PAR1 specific and is mediated by RhoA and Rho kinase
Huang et al., J Biol Chem 2007 (Calcium Signaling) : Subsequent experiments revealed that Myr-G ( 13 ) SRI ( pep ) specifically bound to platelet RhoA guanine nucleotide exchange factor ( p115RhoGEF ) and blocked PAR1 mediated RhoA activation in platelets and human embryonic kidney cells
Loberg et al., J Cell Biochem 2007 (Prostatic Neoplasms) : PAR1 mediated RhoA activation facilitates CCL2 induced chemotaxis in PC-3 cells
Tauseef et al., Circ Res 2008 (Pulmonary Edema) : In SPHK1 depleted cells, PAR-1 activation failed to induce Rac1 activation but augmented RhoA activation and endothelial hyperpermeability response
Soh et al., Proc Natl Acad Sci U S A 2011 : Activation of PAR1 by the coagulant protease thrombin results in Ras homolog gene family member A (RhoA) activation, disassembly of adherens junctions, and disruption of the endothelial barrier