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JUN — LPA

Text-mined interactions from Literome

Ediger et al., Eur Respir J 2003 (Cell Transformation, Neoplastic...) : LPA and EGF both activated activator protein (AP)-1 , cyclic adenosine monophosphate response element binding protein, nuclear factor of activated T-cells and the serum response element ; however, only AP-1 activation exhibited synergism
Fang et al., J Biol Chem 2004 (Ovarian Neoplasms) : The optimal response of the IL-8 gene promoter to LPA relied on binding sites for NF-kappaB and AP-1 , two transcription factors that were strongly activated by LPA in ovarian cancer cell lines
Saatian et al., Biochem J 2006 : Similarly, JNK ( i ) II only blocked LPA mediated phosphorylation of JNK and c-Jun , AP-1 transcription and IL-8 promoter mediated luciferase reporter activity, without blocking p38 MAPK dependent NF-kappaB transcription
Oyesanya et al., Molecular cancer 2010 (Neoplasm Invasiveness) : In ovarian cancer cells highly responsive to LPA, activation of AP-1 by LPA was suppressed by inhibition of EGFR, an effect that could be reversed by co-stimulation of another receptor tyrosine kinase c-Met with hepatocyte growth factor, indicating that LPA mediated activation of AP-1 requires activity of a RTK, not necessarily EGFR
Singla et al., Am J Physiol Gastrointest Liver Physiol 2012 : LPA also increased the protein expression of c-Fos and c-Jun in Caco-2 cells
Chua et al., Biochim Biophys Acta 1998 : Electrophoretic mobility shift assay revealed that LPA stimulated the binding of AP-1
Sasaki et al., J Biochem 1998 : Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts
Cook et al., Mol Cell Biol 1999 : c-Fos, c-Jun , and JunB are induced rapidly in response to LPA stimulation, whereas Fra-1 and Fra-2 are induced after a significant lag ... LPA stimulated expression of c-Fos, Fra-1, Fra-2, c-Jun , and JunB is inhibited by the MEK1 inhibitor PD098059, indicating that the Raf-MEK-MAPK cascade is required for their expression