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JAK1 — LEP
Text-mined interactions from Literome
Carvalheira et al., Biol Chem 2003
:
Interaction between
leptin and insulin signaling pathways differentially
affects JAK-STAT and PI 3-kinase mediated signaling in rat liver
Ishida-Takahashi et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
To clarify the molecular mechanism by which GCs rapidly reduce
leptin induced
JAK/STAT signaling, we examined the intracellular signal transduction pathway potentially mediated by GCs ... PD98059, a specific MEK inhibitor, blocked the inhibitory effects of GCs on
leptin induced
JAK/STAT activation in Huh7 cells
Laubner et al., Diabetes 2005
(Insulinoma...) :
These results suggest that SOCS3 represents a transcriptional inhibitor of preproinsulin gene expression, which is
induced by
leptin through
JAK-STAT3/5b signaling in pancreatic beta-cells ... In conclusion, although SOCS3 is believed to be a negative feedback regulator of JAK-STAT signaling, our findings suggest involvement of SOCS3 in a direct gene regulatory pathway downstream of
leptin activated
JAK-STAT signaling in pancreatic beta-cells
Leung et al., Kidney Int 2006
:
The Janus kinase-signal transducers and activation (
JAK-STAT ) signal transduction pathway in mesothelial cells was
activated by either exogenous or adipocytes derived
leptin
Abdennebi-Najar et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2011
:
Systemically administered PEG-MLA effectively blocks
leptin signal
induction of hypothalamic
JAK-STAT signaling
Zhou et al., Cell Mol Life Sci 2012
(Obesity) :
The peptide hormone
leptin , produced from adipocytes,
activates Jak/Stat3 signaling at the hypothalamus to control food intake, energy expenditure, and fat metabolism
Lu et al., Fish Physiol Biochem 2012
:
Overall, our results provided evidence that
Lep directly
stimulated JAK-STAT signaling mediated lipolysis and fatty acid ß-oxidation gene expression in the fatty degenerated hepatocytes of C. idellus and inhibited the adipogenesis mediated by the IRS-PI(3)K signaling pathway
Pijet et al., Cytokine 2013
(MAP Kinase Signaling System) :
Detailed acute and chronic studies with the use of metabolic inhibitors revealed that both
JAK/STAT3 and MEK/MAPK but not PI3-K/AKT/GSK-3ß signaling pathways were
activated by
leptin , and that STAT3 ( Y ( 705 ) P-STAT3 ) and MEK ( T ( 202/ ) Y ( 204 ) P-ERK1/2 ) mediate these effects
McCowen et al., Endocrinology 1998
:
By contrast,
leptin did not
increase the phosphorylation of
Janus kinase proteins, mitogen activated protein kinase, or STAT1 and -5 despite abundant expression of these signaling molecules in the hypothalamus