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GNA12 — RHOA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/G12/GTP complex (EDNRA-EDN1-GNA12)
→
Rho family GTPase (RAC1/RHOA/CDC42)
(modification, activates)
Gohla et al., J Biol Chem 1999, Nishida et al., J Biol Chem 2007
-
NCI Pathway Database Endothelins:
ETA receptor/Endothelin-1/G12/GTP complex (EDNRA-EDN1-GNA12)
→
Rho Family GTPase-active (RHOA/CDC42/RAC1)
(modification, activates)
Gohla et al., J Biol Chem 1999, Nishida et al., J Biol Chem 2007
-
NCI Pathway Database S1P2 pathway:
S1P/S1P2/G12/G13 complex (S1PR2-GNA12-GNA13)
→
RhoA (RHOA)
(modification, activates)
Okamoto et al., Mol Cell Biol 2000*, Sugimoto et al., Mol Cell Biol 2003, Ikeda et al., Biochem Biophys Res Commun 2004*, Gonda et al., Biochem J 1999
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Nagao et al., Oncogene 1999
:
The activation of JNK by
Galpha12Q229L was
inhibited by dominant negative
RhoA ( T19N ), and botulinum C3 exoenzyme which specifically inactivates Rho
Booden et al., Mol Cell Biol 2002
:
Activated G alpha q, as well as
G alpha 12 and G alpha 13, cooperated with LARG and
caused synergistic activation of
RhoA , suggesting that all three G alpha subunits stimulate LARG mediated activation of RhoA
Dutt et al., Cell Signal 2004
:
proto-Lbc mutant expression also led to decreased levels of
Galpha12 induced
RhoA activation in vivo
Lutz et al., J Biol Chem 2005
:
We further demonstrate that active G alpha ( q ) or G alpha11, but not
G alpha12 or G alpha13, strongly
enhances p63RhoGEF induced
RhoA activation by direct protein-protein interaction with p63RhoGEF at its C-terminal half
Tateiwa et al., Biochem Biophys Res Commun 2005
:
Socius, a novel binding partner of Galpha12/13, promotes the
Galpha12 induced
RhoA activation ... Furthermore, Socius promotes the
Galpha(12) induced
RhoA activation in 293T cells