Gene interactions and pathways from curated databases and text-mining

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GRAP2 — PPARGC1A

Text-mined interactions from Literome

Akimoto et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Furthermore, the p38 mediated increase in Pgc-1alpha promoter activity was enhanced by increased expression of the downstream transcription factor ATF2 and completely blocked by ATF2DeltaN, a dominant negative ATF2
Luo et al., J Mol Neurosci 2009 (Reperfusion Injury) : Furthermore, increase of PGC-1alpha resulted in activation of N-methyl-D-aspartate ( NMDA ) receptor, p38 , and ERK mitogen activated protein kinase ( MAPK ) pathway ... At the same time, PD98059 ( ERK MAPK inhibitor ) and SB203580 ( P38 MAPK inhibitor ) also prevented the up-regulation of PGC-1alpha in OGD neurons and MK801 can inhibit the expression of P38 and ERK MAPK
Pogozelski et al., PloS one 2009 (MAP Kinase Signaling System...) : Gene transfer mediated overexpression of a dominant negative form of p38gamma , but not that of p38alpha or p38beta, blocked motor nerve stimulation induced Pgc-1alpha transcription