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CDK1 — MATK
Text-mined interactions from Literome
Zhu et al., Mol Cell Biol 2004
(Genomic Instability) :
We found that overreplication caused by depletion of geminin activated both Chk1 and
Chk2 , which then phosphorylated Cdc25C on Ser216, resulting in its sequestration outside the nucleus, thus
inhibiting cyclin
B-Cdc2 activity
Krämer et al., Nat Cell Biol 2004
:
Chemical inhibition of
Chk1 resulted in premature centrosome separation and activation of centrosome associated
Cdk1
Jin et al., Oncogene 2005
(Leukemia) :
These results indicate that hematopoietic cytokines protect etoposide treated cells from DNA damage induced apoptosis by promoting, through the PI3K/Akt/GSK3 signaling pathway, G2/M checkpoint that is dependent on
Chk1 mediated inhibition of
Cdc2
Caino et al., Mol Pharmacol 2007
(Adenocarcinoma, Bronchiolo-Alveolar...) :
Mechanistic studies revealed that BPD caused a DNA damage response,
Chk1 activation , and accumulation of
phospho-Cdc2 ( Tyr15 ) in H358 cells, effects that were impaired by an ataxia-telangectasia mutated ( ATM ) /ATM related (ATR) inhibitor
Davoli et al., Cell 2010
(Aneuploidy...) :
Live-cell imaging revealed that these cells have an extended G2 due to ATM/ATR- and
Chk1/Chk2 mediated
inhibition of
Cdk1/CyclinB and eventually bypass mitosis
Du et al., PloS one 2013
(Ovarian Neoplasms) :
SB225002 induced mitotic catastrophe appeared to be mediated by down-regulation of checkpoint kinase
Chk1 and
Cdk1-cyclin B
activation