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CYLD — RELA

Text-mined interactions from Literome

Trompouki et al., Nature 2003 : CYLD inhibits activation of NF-kappaB by the TNFR family members CD40, XEDAR and EDAR in a manner that depends on the deubiquitinating activity of CYLD ... Downregulation of CYLD by RNA mediated interference augments both basal and CD40 mediated activation of NF-kappaB
Kovalenko et al., Nature 2003 : The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
Regamey et al., J Exp Med 2003 : Because TRIP is an inhibitor of nuclear factor (NF)-kappaB activation by tumor necrosis factor (TNF), the effect of CYLD on NF-kappaB activation was investigated in HeLa cells
Jono et al., J Biol Chem 2004 (Inflammation) : NF-kappaB is essential for induction of CYLD , the negative regulator of NF-kappaB : evidence for a novel inducible autoregulatory feedback pathway ... The present study revealed a novel autoregulatory feedback pathway through which activation of NF-kappaB by TNF-alpha and bacterium nontypeable Haemophilus influenzae ( NTHi ) induces CYLD that in turn leads to the negative regulation of NF-kappaB signaling ... In addition, TRAF2 and TRAF6 appear to be differentially involved in NF-kappaB dependent induction of CYLD by TNF-alpha and NTHi
Reiley et al., Mol Cell Biol 2005 : Interestingly, the CYLD phosphorylation requires IkappaB kinase gamma (IKKgamma) and can be induced by IKK catalytic subunits
Chu et al., Cancer Biol Ther 2006 (Carcinoma, Hepatocellular...) : In conclusion : CYLD inhibits TRAIL mediated NF-kappaB activation and enhances the sensitivity of HCC cells to TRAIL triggered apoptosis
Hellerbrand et al., Carcinogenesis 2007 (Carcinoma, Hepatocellular...) : Recent studies suggested a role for CYLD in nuclear factor-kappaB (NF-kappaB) regulation
Fukuda et al., In Vivo 2006 (Carcinoma, Adenoid Cystic...) : CYLD has deubiquitinating enzyme activity and inhibits the activation of transcription factor NF-kappaB
Jin et al., J Biol Chem 2007 (Hyperplasia) : These findings demonstrate a critical role for CYLD in regulating the basal activity of NF-kappaB and maintaining the naive phenotype and proper activation of B cells
Lim et al., PloS one 2007 (Haemophilus Infections...) : NTHi induced CYLD , in turn, negatively regulates NTHi induced NF-kappaB activation through deubiquitinating TRAF6 and 7 and down-regulates inflammation
Wright et al., Dev Cell 2007 : Interestingly, the loss of CYLD in testicular cells leads to activation of the transcription factor NF-kappaB and aberrant expression of antiapoptotic genes ... We further show that CYLD negatively regulates a ubiquitin dependent NF-kappaB activator, RIP1
Fukuda et al., Oncol Rep 2008 (Carcinoma, Adenoid Cystic...) : CYLD , a tumor suppressor gene, has deubiquitinating enzyme activity and inhibits the activation of transcription factor NF-kappaB
Kim et al., J Immunol 2009 : We also show that upon macrophage stimulation, p62 binds to TNFR associated factor 6, another E3 ligase important for NF-kappaB activation, but later this interaction was replaced by the recruitment of the deubiquitinating enzyme, cylindromatosis , an inhibitor of NF-kappaB activity
Sun et al., Cell Death Differ 2010 : By deconjugating these K63 linked ubiquitin chains, CYLD negatively regulates NF-kappaB activation, which may contribute to its tumor suppressor function
Lee et al., EMBO J 2010 : Interestingly, loss of CYLD causes constitutive NF-kappaB activation in developing NKT cells, which contributes to their defective IL-7 response and attenuated ICOS expression
Lee et al., J Biol Chem 2010 : T cell receptor stimulated NF-kappaB activation requires CARMA1 and is negatively regulated by the deubiquitinase CYLD ... We show that CYLD deficiency causes constitutive NF-kappaB activation in thymocytes, which is associated with enhanced frequency of Treg cells ... Interestingly, although loss of CYLD causes NF-kappaB activation in the CARMA1-deficient thymocytes, the CYLD deficiency fails to rescue the defect of CARMA1 knock-out mice in Treg development
Byun et al., Mediators Inflamm 2010 (Cholesteatoma, Middle Ear) : We found that CYLD reduced and activated increased NF-kappaB in cholesteatoma epithelium in comparison to RA skin