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GJA1 — TNF
Text-mined interactions from Literome
Eugenín et al., J Immunol 2003
(Inflammation) :
TNF-alpha plus IFN-gamma
induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses ... In this work, the
effects of bacterial LPS,
TNF-alpha , and IFN-gamma on gap junctional communication ( dye coupling ) and on the expression of
connexin43 ( immunofluorescence, immunoblotting, and RT-PCR ) in monocytes/macrophages were studied
Hao et al., Invest Ophthalmol Vis Sci 2005
:
Immunofluorescence analysis revealed that
TNF-alpha reduced the level of specific staining for
Cx43 at sites of contact between adjacent cells
Meilleur et al., Endocrinology 2007
:
TNF-alpha did not
affect total cell
Cx43-PP2A catalytic subunit interaction, but it did induce PP2A catalytic subunit recruitment to the Triton X-100 insoluble subcellular fraction, in which Cx43-gap junction plaques are recovered
Sharrow et al., Exp Cell Res 2008
:
TNFalpha or TRAIL
reduced connexin43 further ... Serum starvation,
TNFalpha and TRAIL
augmented connexin43 degradation and connexin43 transcription
Tacheau et al., J Cell Physiol 2008
:
TNF-alpha represses
connexin43 expression in HaCat keratinocytes via activation of JNK signaling ... We demonstrate that
TNF-alpha reduces the expression of
Cx43 in HaCat cell lines at the protein and mRNA levels, and transcriptionally ... Using pharmacological inhibitors of the NFkappaB signaling pathway, we determined that the NFkappaB signaling cascade is not implicated in
TNF-alpha effect on
Cx43 expression and in the subsequent decrease of GJIC ... Conversely, in NFkappaB essential modulator ( NEMO ( - ) ) fibroblasts, lack of NFkappaB activation did not influence both the
effect of
TNF-alpha on
Cx43 expression and on GJIC
Heinrich et al., PloS one 2011
(Urinary Bladder, Overactive) :
Therefore, we investigate the
effect of interleukin (IL) 4, IL6, IL10,
tumor necrosis factor-alpha ( TNFa ) and transforming growth factor-beta1 ( TGFß1 ) on GJIC, and
Cx43 and Cx45 expression in cultured human bladder smooth muscle cells ( hBSMC ) and human suburothelial myofibroblasts ( hsMF )
Shaikh et al., Neurochem Int 2012
:
TNF-a induced gap junctional/hemichannel opening whereas blocking TNFRII inhibited
TNF-a induced increase in
Cx43 levels
Lin et al., Cytokine 2013
:
Simvastatin attenuates the additive
effects of
TNF-a and IL-18 on the
connexin 43 up-regulation and over-proliferation of cultured aortic smooth muscle cells ... Mechanistic investigation using kinase-specific inhibitors showed that simvastatin pretreatment attenuated TNF-a elicited Akt and ERK1/2 phosphorylation, whereas PI3K and all MAPK activities were also implied in the additive
effect of
TNF-a and IL-18 on
Cx43 up-regulation ... In conclusion, simvastatin attenuates the additive
effects of
TNF-a and IL-18 on
Cx43 up-regulation and over-proliferation of aortic SMCs, mainly through the blockade of Akt signaling pathway
Kimura et al., Curr Eye Res 2013
(Keratitis...) :
We have now examined the role of mitogen activated protein kinase ( MAPK ) signaling pathways in
TNF-a induced downregulation of the gap junction protein
connexin43 (Cx43) in human corneal fibroblasts ... Results :
TNF-a reduced the abundance of
Cx43 in human corneal fibroblasts ( as revealed by immunoblot analysis ) as well as induced the loss of specific staining for this protein ( as revealed by immunofluorescence analysis ) ... Conclusions : The inhibitory
effects of
TNF-a on
Cx43 expression and GJIC in human corneal fibroblasts are mediated, at least in part, by the JNK signaling pathway, which therefore likely plays a role in corneal inflammation