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A2M — FGF2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
FGF2
→
Complex of A2M-FGF2
(directlyDecreases)
Evidence: Both apha2M and a2M* bind a variety of cytokines and growth factors, including FGF1, FGF2, FGF4, and FGF6, but not FGF5, FGF7, FGF9, and FGF10 [161]. The binding of a2M to FGF2 occurs with high affinity (Table 1) and is primarily hydrophobic in nature [162]. a2M sequesters FGF2 in the extracellular environment and inhibits its cell interaction, protease-inducing activity [163] and mitogenic capacity [161].
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bonner et al., J Biol Chem 1992
:
Other cytokines that bind alpha 2M ( transforming growth factor-beta 1 and -beta 2, tumor necrosis factor-alpha, basic fibroblast growth factor, interleukin -1 beta, and -6 ) did not compete for 125I-PDGF-BB binding slow alpha 2M, but transforming growth factor-beta 1 and
basic fibroblast growth factor inhibited 125I-PDGF-BB binding
alpha 2M-methylamine by 30-50 %
Savona et al., Growth Factors 1994
:
Synergistic
induction of
alpha 2-macroglobulin synthesis by
fibroblast growth factor-2 and transforming growth factor beta 1 in bovine adrenocortical cells ... We report here that
basic fibroblast growth factor ( FGF-2 ), a potent mitogen for adrenocortical cells,
stimulates the expression of
alpha 2-macroglobulin by these cells at a transcriptional level and is synergistic with TGF beta 1 for this effect ... This is supported by the following observations : ( i ) Treatment of adrenocortical cells by FGF-2 resulted in a time dependent and dose dependent increase of alpha 2M synthesis, ( ii ) FGF-2 did not modify alpha 2M secretion rate ; ( iii ) The
induction of
alpha 2M synthesis by
FGF-2 was not observed in the presence of the transcription inhibitor DRB ; ( iv ) The amount of alpha 2M mRNA was increased by 2 to 3 fold under either FGF-2 or TGF beta 1 treatment ; ( v ) Optimal doses of TGF beta and FGF-2 synergistically increased alpha 2M synthesis