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ACAN — FGF2
Text-mined interactions from Literome
Sandell et al., Osteoarthritis Cartilage 2008
(Arthritis) :
In the presence of IL-1beta,
FGF-18 increased expression of ADAMTS-4,
aggrecan , BMP-2, COL2A1, CCL3, CCL4, CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6, and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Wang et al., Growth Factors 2009
:
FGF2 , IL-1beta, and TSA
inhibited expression of
aggrecan , while TSA also decreased mRNA levels of collagen type II
Ando et al., Acta Orthop 2009
:
The presence of BMP-2 and
bFGF clearly
enhanced the
aggrecan and type II collagen expression of 3D-embedded chondrocytes
Yan et al., J Cell Biochem 2012
:
Quantitative PCR analyses revealed that both Ras and PKCd contributed to
FGF-2 mediated upregulation of MMP-13, ADAMTS5, and repression of
aggrecan gene
Chandrasekhar et al., Agents Actions Suppl 1993
:
Finally, with respect to proteoglycan synthesis, TGF-beta, PDGF and IGF-1 reversed IL-1 induced PG suppression to different extents, while
FGF slightly potentiated IL-1
induced suppression of
aggrecan synthesis