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TLR4 — TLR9

Text-mined interactions from Literome

An et al., Immunology 2002 : While inhibition of extracellular signal related kinase and NF-kappaB activation suppressed the up-regulation of the expression of TLR2, TLR4 and TLR9 mRNA, inhibition of p38 kinase prevented the up-regulation of TLR2 and TLR4 mRNA expression but enhanced the up-regulation of TLR9 expression
Zhang et al., FEBS Lett 2002 : Co-expression of the alphav-TLR and beta5-TLR chimeras in 293T cells generated 10 TLR homodimers, but only TLR4/4 could effectively activate NF-kappaB
Coccia et al., Eur J Immunol 2004 : TLR-9 stimulation by CpG DNA induced the expression of all IFN-alpha, -beta, -omicron and -lambda subtypes in pDC, whereas TLR-4 stimulation by LPS, or TLR-3 stimulation by poly I:C, induced only IFN-beta and IFN-lambda gene expression in MDDC
Duez et al., Eur J Dermatol 2006 (Asthma...) : During the allergic reaction, TLR engagement on DC directs the polarization of the T cell response and, while TLR2 and TLR4 may favour both Th1 and Th2 responses, TLR9 induces the development of regulatory T cells
Cabral et al., J Infect Dis 2006 : TLR4 stimulation had no effect on TLR2, TLR1 , and TLR5 expression
Mueller et al., J Immunol 2006 : TLR4/MD-2 mediated LPS uptake and TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Asakura et al., Am J Hematol 2007 : Serine/threonine kinase PKR : a sentinel kinase that discriminates a signaling pathway mediated by TLR4 from those mediated by TLR3 and TLR9
Furuta et al., Eur J Immunol 2008 (Malaria) : Innate immune responses to PbAPrx were examined using cells from mice deficient in Toll-like receptors ( TLR ) or related molecules, and it was demonstrated that responses were severely impaired in TLR4 ( -/- ), MyD88 ( -/- ) and MD-2 ( -/- ) mice, but not in Toll/IL-1 receptor domain containing adaptor inducing IFN-gamma ( TRIF ) ( -/- ), TLR2 ( -/- ) or radioprotective 105 ( RP105 ) ( -/- ) mice
van de Veerdonk et al., Immunobiology 2008 (Candidiasis) : In conclusion, TLR9 is a pathogen-recognition receptor for C. albicans, and TLR9 is involved in the induction of cytokines in response to C. albicans
Kimman et al., PloS one 2008 : Activation of the Toll-like receptor ( TLR ) signaling pathway through TLR4 may be important in the induction of protective immunity against Bordetella pertussis with TLR4 mediated activation of dendritic and B cells, induction of cytokine expression, and reversal of tolerance as crucial steps
Regueiro et al., Infect Immun 2009 : We showed that Klebsiella induced TLR2 and TLR4 upregulation was dependent on TLR activation
Gribar et al., J Immunol 2009 (Enterocolitis, Necrotizing) : Activation of TLR9 with CpG-DNA inhibited LPS mediated TLR4 signaling in enterocytes in a mechanism dependent upon the inhibitory molecule IRAK-M
Messlik et al., J Proteome Res 2009 (Chronic Disease...) : The aim of this study was to characterize the role of TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
Jagannathan et al., J Immunol 2009 (Chronic Periodontitis) : TLR2 and TLR9 also regulate B cell TLR4 expression, demonstrating that TLR cross-talk controls B cell responses at multiple levels
van Bruggen et al., J Innate Immun 2010 (Bacterial Infections...) : Surprisingly, the reactivity towards certain established TLR ligands, imiquimod and ODN-CpG, was unaffected by IRAK-4 deficiency, demonstrating their activity is independent of TLR. TLR-4 dependent signaling in neutrophils was totally dependent on IRAK-4 without any major TRIF mediated contribution
Yang et al., J Exp Clin Cancer Res 2010 (Breast Neoplasms) : TLR4AsiRNA, TLR4BsiRNA and TLR4CsiRNA were found to significantly inhibit TLR4 expression in MDA-MB-231 at both mRNA and protein levels as compared to vector control ( vector transfected cells )
Kim et al., FEMS Microbiol Lett 2012 (Inflammation) : L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2, TLR4 , and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative regulator of TLR ... L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2, TLR4, and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative regulator of TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011 : CD14, TLR4 receptors are involved in P.e-LPS effect and CD14, TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast
Kwissa et al., Blood 2012 : In the draining lymph nodes ( LNs ), consistent with the effects in blood, all TLR-Ls induced expansion of CD14 ( + ) monocytes, but only TLR7/8-L and TLR9-L expanded the activated CD14 ( + ) CD16 ( + ) cells
Raicevic et al., Tissue Eng Part A 2012 : Inflammation was mimicked by a cytokine cocktail, and TLR activation was induced through TLR3 and TLR4 ligation
Neal et al., J Biol Chem 2012 (Enterocolitis, Necrotizing) : To define molecular mechanisms involved, TLR4 inhibited ISC proliferation and increased apoptosis via the p53-up regulated modulator of apoptosis ( PUMA ), as TLR4 did not affect crypt proliferation or apoptosis in organoids or mice lacking PUMA
Deng et al., Immunol Cell Biol 2013 : The TLR signals that regulate the phagocytic ability of macrophages were also induced by TLR4 and TLR5 activation
Zhao et al., Fish Shellfish Immunol 2013 (Ciliophora Infections...) : TLR9 was induced in the skin and gill, whereas TLR21 was induced in the head kidney and spleen after infection