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CRH — GJA1

Text-mined interactions from Literome

Wu et al., Am J Physiol Endocrinol Metab 2007 : Corticotropin releasing hormone activates connexin 43 via activator protein-1 transcription factor in human myometrial smooth muscle cells ... The aim of the present study was to investigate the regulatory effects of CRH on Cx43 expression in human myometrial smooth muscle cells ( SMCs ) and, potentially, its activation of the c-Fos/activator protein (AP)-1 signaling pathway ... CRH significantly increased mRNA and protein expression of c-Fos and Cx43 in a dose dependent manner ( P < 0.01 ). A transient transfection of AP-1 decoy ODN did not affect CRH regulation of c-Fos ( P > 0.05 ) but almost completely abolished CRH induced enhancement of Cx43 expression ( P < 0.01 ) ... Blockade of AP-1 sites to the Cx43 promoter can neutralize the CRH induced upregulation of Cx43
Hu et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013 : CRH can enhance the expression of P-Cx43 and the function of gap junction intercellular communication in the primary cultured myometrial SMCs