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CSF3 — JAK3
Text-mined interactions from Literome
Koay et al., Cell Signal 2002
(MAP Kinase Signaling System) :
The G-CSFR membrane proximal region containing the Box 2 homology sequence was determined to be critical for proliferative signaling, as well as for
activation of
Janus kinase ( JAK2 ) and p44/42 mitogen activated protein kinase ( MAPK ) following
G-CSF stimulation
Wang et al., Oncogene 2002
:
Antisense inhibition of c-Cbl expression in DT40GR cells led to enhanced
Jak-STAT activation following
G-CSF stimulation
Mangan et al., Oncogene 2006
:
Granulocyte colony stimulating factor induced upregulation of
Jak3 transcription during granulocytic differentiation is mediated by the cooperative action of Sp1 and Stat3 ... To gain insight into the regulation of
G-CSF induced transcription of
Jak3 , we constructed deletion and linker scanning mutants of the Jak3 promoter sequences and performed luciferase reporter assays in the murine myeloid cell line 32Dcl3, with and without G-CSF stimulation
Shih et al., PloS one 2012
:
Furthermore, aciculatin significantly inhibited the
G-CSF mediated phosphorylation of Janus kinase-signal transducer and activator of transcription (
JAK-STAT ) and Akt and neutrophil differentiation from precursor cells