◀ Back to MAPK3
MAPK3 — YWHAB
Pathways - manually collected, often from reviews:
-
NCI Pathway Database PDGFR-beta signaling pathway:
Erk1-2 (MAPK3/MAPK1)
→
KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2)
(modification, collaborate)
Taylor et al., Endocrinology 2000, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
Evidence: assay, physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
KSR/14-3-3 (dimer)/MEK1-2-active complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MAP2K1_MAP2K2)
→
Erk1-2-active (MAPK3/MAPK1)
(modification, activates)
Taylor et al., Endocrinology 2000, Ory et al., Curr Biol 2003, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
Evidence: assay, physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
Erk1-2-active (MAPK3/MAPK1)
→
RAF1/14-3-3 complex (RAF1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(modification, activates)
Brummer et al., Oncogene 2003, Dougherty et al., Mol Cell 2005, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
Evidence: assay, physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
Erk1-2-active (MAPK3/MAPK1)
→
RAF1/BRAF/14-3-3/14-3-3 complex (RAF1-BRAF-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(modification, activates)
Brummer et al., Oncogene 2003, Dougherty et al., Mol Cell 2005, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
Evidence: assay, physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
Erk1-2-active (MAPK3/MAPK1)
→
BRAF/14-3-3 complex (BRAF-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(modification, activates)
Brummer et al., Oncogene 2003, Dougherty et al., Mol Cell 2005, McKay et al., Proc Natl Acad Sci U S A 2009, Ritt et al., Mol Cell Biol 2010
Evidence: assay, physical interaction
Text-mined interactions from Literome
Trakul et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
Because c-Raf-1 and
B-Raf are both
required for maximal
MAPK stimulation by epidermal growth factor in neuronal and epithelial cell lines, we determined whether RKIP significantly affects MAPK signaling
Burger et al., Eur Urol 2006
(Microsatellite Instability...) :
The present study investigated
B-RAF mutations, MSI status, and
activation of
MAPK signaling in prostate tumors
Yue et al., Oncogene 2006
:
No changes in the activity of B-Raf were detectable during progesterone induced oocyte maturation, after egg fertilization, or during the early embryonic cell cycle, arguing against a
role for
B-Raf in the mitotic activation of MEK1 and p42
MAPK ... We found that both
B-Raf and C-Raf, but not Mos, are
required for Ras induced MEK1 and p42
MAPK activation
Hao et al., Mol Cancer Ther 2007
(Colorectal Neoplasms...) :
These observations suggest that inhibition of
B-Raf activation of
mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK ) and the extracellular signal regulated kinase MAPK cascade may be an effective approach for the treatment of RAS and B-RAF mutation positive melanomas and colon carcinomas
Denis-Henriot et al., Endocrinology 1998
:
Wild-type Galpha12 overexpression prevented the decrease in
MAPK activity and
induced MEK1, but not
B-Raf , expression