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IL2 — REL
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Grumont et al., J Exp Med 2001
:
c-Rel regulates
interleukin 12 p70 expression in CD8 ( + ) dendritic cells by specifically inducing p35 gene transcription
Iwashima et al., Proc Natl Acad Sci U S A 2002
:
Activation of
c-Rel using the estrogen receptor fusion protein
restored the activation of the
IL-2 promoter in an estrogen dependent manner
Rao et al., J Immunol 2003
:
We initially showed that
IL-2 gene transcription in CD4 ( + ) primary T cells is
dependent on the NF-kappaB family member,
c-Rel , but not RelA
Tan et al., Mol Cell Biol 1992
:
On the basis of this homology, we examined the potential
role of
c-Rel in controlling
IL-2R alpha transcription ... We found that human
c-Rel can
activate transcription from the
IL-2R alpha promoter, but not the kappa B-containing human immunodeficiency virus type 1 promoter, upon cotransfection into Jurkat T cells
Temmerman et al., Blood 2006
(Ectodermal Dysplasia...) :
As a consequence, CD40 stimulated EDI DCs failed to synthesize the
c-Rel dependent cytokine
interleukin-12 , had impaired up-regulation of costimulatory molecules, and failed to support allogeneic lymphocyte proliferation in vitro
Touma et al., J Immunol 2007
:
Transfection analysis demonstrates that I kappa BNS and
c-Rel individually
increase IL-2 promoter activity
McKarns et al., J Immunol 2008
:
Late-phase
Il2 expression mostly
requires c-Rel , CD28, and TNFR signaling
Visekruna et al., Eur J Immunol 2010
:
Mechanistically, in vitro conversion of naive CD4 ( + ) T cells into iTreg was crucially dependent on
c-Rel mediated synthesis of endogenous
IL-2
Shindo et al., Cytokine 2011
:
We also demonstrated that
IL-2 production was also
enhanced by exogenously expressed IRF-4 and
c-Rel in the presence of P/I, in T-cells, and that the optimal IL-2 and IL-4 productions in vivo was IRF-4 dependent using IRF-4-/- mice
Grigoriadis et al., PloS one 2011
:
While the subsequent
IL-2 induction of Foxp3 in nTreg precursors
requires c-Rel , this developmental transition does not coincide with the nuclear expression of c-Rel
Ballard et al., Cell 1990
:
v-Rel , but not nontransforming v-Rel mutants, binds to the kappa B enhancer and
inhibits NF-kappa B-activated transcription from the
IL-2 receptor alpha promoter and HIV-1 LTR
Poke et al., PloS one 2012
:
The nuclear activation of
c-Rel therefore not only
regulates the initiation of GM-CSF and
IL-2 gene activation in response to T cell activation, but also the termination of these gene responses following the removal of the activating signal
Good et al., EMBO J 1996
:
In the present study, we demonstrate that neither NF-kappa
B/Rel nor CREB/ATF is
sufficient for Tax mediated activation of the
IL-2 promoter
Parra et al., J Immunol 1998
:
The
role of
Rel and activation protein-1 (AP-1) in
IL-2 promoter activity in B7-1- and leukocyte function associated Ag-3 ( LFA. 3 ) -costimulated T cells has been evaluated