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PTGS2 — TIMP1

Text-mined interactions from Literome

Han et al., Mech Ageing Dev 2004 (Arthritis, Rheumatoid...) : The selective COX-2 inhibitor, NS-398, can inhibit the senescence associated increases of COX-2, PGE ( 2 ), p53 and MMP-1 expression, and the senescence associated decreases of PCNA, TIMP-1 and procollagen expression
Takaoka et al., Int J Oncol 2006 (Carcinoma...) : These results indicated that overexpression of COX-2 elevated tumorigenicity, tumor growth and invasion of human KB carcinoma cells via up-regulated MMP and Rho family small GTPases and down-regulated TIMP activities
Ramer et al., Biochem Pharmacol 2010 : Collectively, this data demonstrate a COX-2 dependent upregulation of TIMP-1 conferring the antimigratory action of cannabinoids