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CDK4 — SP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lu et al., Mol Endocrinol 2000
(Adenocarcinoma...) :
Androgen induction of
cyclin dependent kinase inhibitor p21 gene :
role of androgen receptor and transcription factor
Sp1 complex
Peñuelas et al., Eur J Biochem 2003
:
The expression of the transcription factor
Sp1 , a retinoblastoma interacting protein, was also
enhanced by all the
cyclin dependent kinase inhibitors tested
Tapias et al., Cell cycle (Georgetown, Tex.) 2008
:
CDK4 , SKP2, Rad51, BRCA2 and p21 also
activated the
Sp1 promoter
Willoughby et al., J Biol Chem 2009
(Prostatic Neoplasms) :
Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting
Sp1 interactions with the cyclin dependent kinase-4 (CDK4) promoter and
inhibiting CDK4 gene expression
Chew et al., J Biol Chem 2012
:
Sulforaphane induction of p21 ( Cip1 )
cyclin dependent kinase inhibitor expression
requires p53 and
Sp1 transcription factors and is p53 dependent