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BDNF — GRB2
Pathways - manually collected, often from reviews:
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BioCarta role of erk5 in neuronal survival pathway:
neurotrophin/TRkA complex (NTF3_BDNF_NGFB-NTRK1)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
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NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, activates)
Qian et al., Neuron 1998
Evidence: mutant phenotype, physical interaction, other species
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NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
SH2B family/GRB2/SOS1 complex (GRB2-SOS1)
(modification, activates)
Qian et al., Neuron 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
SHC/GRB2/SOS1 complex (SHC1-GRB2-SOS1)
→
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
(modification, collaborate)
Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
GRB2/SOS1 complex (GRB2-SOS1)
→
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
(modification, collaborate)
Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling:
NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2)
→
FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2)
(modification, activates)
Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
Evidence: mutant phenotype, physical interaction, other species
Text-mined interactions from Literome
Yamada et al., J Neurochem 1999
:
Brain derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and
Grb2 in cultured cerebral cortical neurons
Liang et al., Brain Res 2010
:
We found that both
GRb1 and GRg1 were capable of
increasing the proliferation of, and the expression and secretion of NGF and
BDNF in Schwann cells ... These findings indicate that the beneficial
effects of
GRb1 and GRg1 on proliferation and expression of NGF and
BDNF occurs mainly through the PKA pathway in cultured Schwann cells