Gene interactions and pathways from curated databases and text-mining

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IRF6 — SOD1

Text-mined interactions from Literome

Yu et al., Neurosci Lett 1999 (Glioma) : The mRNA level of magnesium-SOD ( Mn-SOD ) was increased by LPS in both cells while the expression of constituted SOD ( Cu, Zn-SOD ) was not stimulated by LPS
Brandes et al., Hypertension 1999 (Endotoxemia...) : LPS also induced expression of the oxidative stress-sensitive protein manganese superoxide dismutase
Maehara et al., J Cell Biochem 2000 : Expression of the manganese superoxide dismutase ( Mn-SOD ) is induced by tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), and lipopolysaccharide (LPS)
Barreca et al., Growth Horm IGF Res 1998 (Sepsis) : To investigate the potential regulation of ALS by LPS , we measured serum ALS by immunoblot, 5 and 10 h after IP injection of LPS ( 250 or 750 microg/100 g BW vs saline ), in 4-week-old female Wistar rats ( four per group ) ... The decrease in ALS levels in response to LPS was not prevented by exogenous GH
White et al., J Endotoxin Res 2000 : Whether it also inhibits LPS induction of manganese superoxide dismutase ( MnSOD ) is not clear
Ogawa et al., J Immunol 2003 (Inflammation...) : Manganese superoxide dismutase expression increased with repeated LPS stimulation, with a reduction in intracellular superoxide
Klebanov et al., Biofizika 2003 : The effect of lipopolysaccharides (LPS) and low-power laser radiation on nitric oxide ( NO ) production and the activity of superoxide dismutase ( SOD ) in rat peritoneal exudate macrophages was investigated ... It was found that LPS increased NO production and SOD activity in macrophages in a concentration dependent manner ... This implies that the LPS induced increase in SOD activity and NO production were determined by the activation of de novo protein synthesis ( SOD and inducible NO synthase )
Sanchez-Campillo et al., Microbes Infect 2004 : Expression of hepatocyte Mn-SOD is also induced by stimulation with CpG-oligodeoxynucleotides, LPS , and the mix of IFNgamma, IL-1beta and LPS
Wehrwein et al., Cardiovascular diabetology 2006 (Diabetes Mellitus, Type 1) : Monocytes were isolated from controls and T1D patients and the LPS stimulated increase of IL-6, CXCL8, monocyte chemotactic protein 1 ( CCL2, MCP-1 ) and superoxide dismutase ( SOD 2 ), as well as the LPS mediated decrease of apolipoprotein E (Apo E) in primary human monocytes from controls and T1D patients was determined
Nagasaka et al., Biochem Biophys Res Commun 2007 : Cycloartenyl ferulate ( CAF ), one of phytosteryl ferulates, significantly reduced lipopolysaccharide (LPS) induced NO production and mRNA expression of inducible NO synthase and cyclooxygenese-2 but upregulated SOD activity
Xie et al., Int Immunopharmacol 2009 (Acute Disease...) : Consistent with its effects on neutrophil infiltration, LF treatment significantly increased LPS induced BALF superoxide dismutase activity, and significantly decreased lung myeloperoxidase activity as well
Chen et al., Inflammation 2010 (Acute Lung Injury...) : Furthermore, valnemulin significantly increases LPS induced SOD activity in BALF and decreases lung MPO activity as well
Stefanova et al., Z Naturforsch C 2010 (Arthritis, Experimental...) : Yeast SOD treatment effectively suppressed the spontaneous and recombinant mouse IFN-gamma + LPS induced release of NO as well
Laskin et al., J Leukoc Biol 2010 (Acute Disease...) : LPS induced up-regulation of SOD was also reduced in STK-/- mice in liver macrophages and endothelial cells
Visner et al., Am J Physiol 1991 : The induction of Mn SOD by LPS was blocked by both a RNA synthesis inhibitor, actinomycin D, and a protein synthesis inhibitor, cycloheximide
Kaneko et al., Clin Exp Pharmacol Physiol 2012 (Neurodegenerative Diseases) : LPS did not affect the expression of Cu/Zn- and Mn-SOD proteins, nor did it extend the life span of microglia that had mutated Toll-like receptor (TLR) 4
Mokuno et al., J Neurochem 1994 : To determine whether cytokines or lipopolysaccharide (LPS) are involved in the induction of superoxide dismutase ( SOD ) in the nervous system, we examined the effects of these substances on the levels of SOD in cultured mouse astrocytes ... The results indicate that the selective induction of Mn SOD by cytokines and LPS , which has been observed in nonnervous tissues, may also occur in nervous tissues
Liu et al., J Formos Med Assoc 1996 (Gingival Hyperplasia) : To determine whether lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) are involved in the induction of superoxide dismutase ( SOD ) in gingival tissue, we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts
De Leo et al., FEBS Lett 1997 (Liver Neoplasms, Experimental) : Iron modulation of LPS induced manganese superoxide dismutase gene expression in rat tissues
Dobashi et al., J Neurochem 1997 : In spite of the stimulation of mRNA level, LPS and IFN-gamma significantly inhibited the activity of Mn-SOD within the first 24 h of incubation ; however, Mn-SOD activity gradually increased with the increase in time of incubation
Sugino et al., Biol Reprod 1998 : LPS caused an increase in Mn-SOD mRNA levels in the corpus luteum and a decrease in serum progesterone levels, but neither in levels of Cu, Zn-SOD mRNA