Gene interactions and pathways from curated databases and text-mining

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FGR — IGF1

Pathways - manually collected, often from reviews:

  • WikiPathways Focal Adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC → BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 (activation)

Text-mined interactions from Literome

Randhawa et al., Mol Genet Metab 2005 : In humans and mice, mutations or targeted deletions of the IGF ligands IGF1 and IGF2, as well as the IGF type-I receptor and its main signaling molecule IRS1 lead to FGR
Randhawa et al., Pediatr Endocrinol Rev 2008 (Fetal Growth Retardation...) : In humans and mice, mutations or targeted deletions of the IGF ligands IGF1 and IGF2, as well as the IGF type-1 receptor ( IGFR1 ) and its main signaling molecule IRS1 lead to FGR