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TPO — TTF1
Text-mined interactions from Literome
Ogasawara et al., Dev Genes Evol 2000
:
TTF-1 regulates the expression of
TPO , which encodes an iodinating enzyme associated with thyroid hormone synthesis ... A recent study showed that the ascidian TTF-1 and TPO genes are specifically expressed in the endostyle, but that the expression domains of these genes are not overlapping, suggesting that ascidian
TPO is not
regulated by
TTF-1 ... Moreover, the spatial and temporal expression patterns of these genes suggest that
TTF-1 regulates
TPO expression ... The coexpression of these genes in amphioxus suggests that
regulation of
TPO by
TTF-1 was present in the common ancestor of cephalochordates ( acraniates ) and craniates
Fenton et al., Ann Clin Lab Sci 2001
(Disease Progression...) :
Thyroid
transcription factor 1 ( TTF-1 ) is essential for thyroid differentiation and
regulates expression of thyroglobulin,
thyroid peroxidase , sodium/iodide symporter, and thyrotropin receptor ( TSH-R ) genes