◀ Back to IL2

CRKL — IL2

Pathways - manually collected, often from reviews:

• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → CRKL (modification, activates)

Text-mined interactions from Literome

Gesbert et al., J Biol Chem 1998 : Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells
Ozaki et al., Blood 1998 : Furthermore, interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and erythropoietin also induce Crkl-STAT5 complex formation in responding cells in a stimulation dependent manner