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IGFBP2 — PTEN

Text-mined interactions from Literome

Levitt et al., Biochem Biophys Res Commun 2005 (Glioma) : The PTEN induced decrease in IGFBP-2 expression could be mimicked with the PI3-kinase inhibitor LY294002, indicating that the lipid phosphatase activity of PTEN is responsible for the observed effect ... However, the rapamycin analog CCI-779 did not affect IGFBP-2 expression, suggesting that the PTEN induced decrease in IGFBP-2 expression is not attributable to decreased mTOR signalling
Perks et al., Oncogene 2007 (Breast Neoplasms...) : IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells ... Investigating IGF binding protein ( IGFBP ) modulation of IGF-II actions on MCF-7 breast cancer cells, we found that IGFBP-2 also regulates PTEN ... These cells predominantly produce IGFBP-2 : blocking IGFBP-2 with a specific antibody, or preventing IGFBP-2 binding to integrins, restored the induction of PTEN and the cells were non-responsive to high doses of the IGF-II-analog ... Our findings indicate that breast cancer cells do not respond to high doses of IGF-II due to induction of PTEN, but IGFBP-2 , when free from IGF-II can suppress PTEN
Mehrian-Shai et al., Proc Natl Acad Sci U S A 2007 (Brain Neoplasms...) : To further investigate this link, we determined that IGFBP-2 expression is negatively regulated by PTEN and positively regulated by phosphatidylinositol 3-kinase (PI3K) and Akt activation
DeMambro et al., J Bone Miner Res 2012 (Bone Resorption) : Expression of wild-type IGFBP-2 reduced the level of PTEN to that of wild-type cells
Foulstone et al., Endocrinology 2013 (Breast Neoplasms) : Loss of IGFBP-2 increased levels of PTEN and improved chemosensitivity of the cells, confirming its role as a survival factor ... IGFBP-2 not only modulates IGFs and directly regulates PTEN but also has a role in maintaining ER-a expression