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EGF — GNRH1

Text-mined interactions from Literome

Gallo et al., J Neuroendocrinol 2000 : Moreover, bFGF priming counteracted EGF induced decrease in LHRH release and significantly stimulated LHRH secretion following IGF-I or insulin application, suggesting that bFGF may sensitize LHRH neurones to differentiating effects of specific GFs during development
Krebs et al., Oral Oncol 2002 (Laryngeal Neoplasms...) : Up-regulation of LH-RH receptors by epidermal growth factor (EGF) increased the entry and potency of AN-152 in KB cells, but not in HEp-2 cells
Hiney et al., J Stud Alcohol 2003 : We therefore investigated the effects of ETOH on EGF induced LHRH and LH release, both in vivo and in vitro ... ETOH blocked EGF induced PGE2 and LHRH released from isolated median eminences
Liebow et al., Proc Natl Acad Sci U S A 1991 (Pancreatic Neoplasms) : One of the substrates of epidermal growth factor (EGF) stimulated tyrosine kinase activity and LH-RH- and somatostatin stimulated tyrosine phosphatase activity is also a 60-kDa protein ... Competition binding experiments with I125 labeled [ D-Trp6 ] LH-RH by displacement with a nonradioactive ligand showed that the LH-RH binding in 69 % of the points was increased by EGF and 85 % was decreased by RC-160 compared with controls ( n = 61 ; both significant, P less than 0.001 )
Ojeda et al., Proc Natl Acad Sci U S A 1990 : The results indicate that the effect of EGF and TGF-alpha on LHRH release is mediated by the EGF/TGF-alpha receptor and suggest that TGF-alpha rather than EGF may be the physiological ligand for this interaction
Mouihate et al., Life Sci 1996 : These results indicate that EGF is mostly secreted by gonadotrophs and that this EGF release is enhanced by LHRH
Ma et al., Endocrinology 1997 : Although both TGF alpha and EGF stimulate LHRH release, they do not appear to act directly on LHRH neurons, as no EGF/TGF alpha receptors are detected on these cells in vivo