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EGF — ODC1

Text-mined interactions from Literome

Johnson et al., J Physiol Pharmacol 1992 : EGF significantly increased ODC activity in all 3 tissues
Soler et al., Cellular and molecular biology 1992 : Epidermal growth factor (EGF) delayed ODC induction, but only in the presence of amino acids
Elitsur et al., Dig Dis Sci 1991 : We observed that EGF suppressed DNA synthesis and ornithine decarboxylase (ODC) activity in lamina propria lymphocytes
Eggstein et al., J Cancer Res Clin Oncol 1991 (Colonic Neoplasms) : In this study the effect of gastrin, gastrin receptor blockers, epidermal growth factor (EGF) and DFMO on growth and ODC activity of four human colon carcinoma cell lines ( SW 403, SW 1116, LS 174 T and Lovo ) was investigated
Volonté et al., J Biol Chem 1990 (Adrenal Gland Neoplasms...) : Epidermal growth factor (EGF) and cAMP derivatives also induce ODC activity in PC12 cells, and these effects were suppressed by 6-TG and 2-AP at concentrations similar to those that affect responses to NGF
Arlow et al., Life Sci 1990 : An organ culture system was utilized to examine the effect of gastrin ( G-17-I ) and epidermal growth factor (EGF) on colonic mucosal ornithine decarboxylase (ODC) activity, and the expression of the ODC gene
Almazan et al., Brain Res 1985 : Bovine growth hormone ( bGH ) and epidermal growth factor (EGF) increased the activity of ornithine decarboxylase (ODC) in brain cell aggregates cultured in a serum-free chemically defined medium
Goodlad et al., Clin Sci (Lond) 1989 : 1. Intestinal epithelial cell proliferation was measured in rats maintained on total parenteral nutrition (TPN), in TPN rats given 300 micrograms of recombinant human epidermal growth factor ( urogastrone-epidermal growth factor, URO-EGF ) day-1 kg-1, and in further groups given URO-EGF and difluoromethylornithine ( DFMO ), an inhibitor of the enzyme ornithine decarboxylase (ODC)
Rinehart et al., J Cell Physiol 1985 (Neuroblastoma) : Glutamic acid, EGF , and NGF do not induce ODC except in the presence of an inducing amino acid
Chua et al., Mech Ageing Dev 1986 : Ornithine decarboxylase activity was also stimulated by EGF to a comparable level in young and senescent cells
Pisano et al., Dev Biol 1987 : Stimulation of ODC activity by EGF and PGE2 in these cells was not positively correlated with the level of cellular DNA synthesis but did result in a ninefold increase in the synthesis of extracellular glycosaminoglycans ( GAGs ), a key macromolecular family implicated in palatal morphogenesis ... Stimulation of GAG synthesis was significantly inhibited by the administration of 5 mM DFMO ( an irreversible inhibitor of ODC ), indicating that the marked increase in GAG production was dependent, in part, on the induction of ODC activity by EGF and PGE2
Messing et al., Cancer Res 1987 (Carcinoma, Transitional Cell...) : However, EGF induced dose related ODC activity only in the TCC cell lines and not in any of the HU cell cultures
Hiramatsu et al., Acta Med Okayama 1985 : Among these hormones, only insulin, dexamethasone and EGF induced ODC activity and polyamine biosynthesis, especially that of putrescine, in both adult and fetal hepatocytes
Russell et al., Mol Cell Endocrinol 1984 : Epidermal growth factor (EGF) , which did not induce rat kidney ODC activity by itself, was capable of producing a small increment in ODC activity in the presence of CyA
LaCorbiere et al., J Neurosci Res 1981 : Nerve growth factor (NGF), epidermal growth factor (EGF) , adenosine 3',5'-cyclic monophosphate ( cAMP ), and cholera toxin all increase the specific activity of ornithine decarboxylase (ODC) in the PC12 nerve-like cell line
Zheng et al., Biochem J 1995 : Pretreatment of keratinocytes with all-trans-retinoic retinoic acid inhibited the EGF induction of ODC activity ... Blocking of EGF receptors with a neutralizing antibody for EGF receptors inhibited the induction of ODC activity by EGF
Morrison et al., Cardiovasc Res 1995 : In contrast, platelet derived growth factor and epidermal growth factor did not stimulate ODC activity
Taniguchi et al., Br J Dermatol 1995 : CyA ( 5 micrograms/ml ) inhibited ODC activity, ODC mRNA level, and cell growth induced by 50 ng/ml EGF ... Ultraviolet B ( 10 mJ/cm2 ) irradiation suppressed the induction of ODC, ODC mRNA, and cell proliferation stimulated by EGF, but ultraviolet A ( 0-15 J/cm2 ) irradiation inhibited neither EGF stimulated ODC activity nor cell proliferation
Scalabrino et al., Lab Invest 1995 (Nerve Degeneration...) : Nerve growth factor did not induce ODC in either Cbl-D myeloneuropathy ; epidermal growth factor induced ODC in both Cbl-D myeloneuropathies
Zheng et al., Exp Dermatol 1993 : We previously demonstrated that epidermal growth factor (EGF) induces a several-fold increase in ornithine decarboxylase (ODC) activity and the steady-state level of ODC mRNA in cultured SV40 transformed human keratinocytes ( 1 ) ... Pretreatment of cell cultures with ultraviolet B ( UVB ) radiation resulted in a reduction of EGF induced ODC activity
Ishikawa et al., Life Sci 1994 (Stomach Neoplasms) : Effect of epidermal growth factor (EGF) on ornithine decarboxylase (ODC) was examined in human gastric cancer derived KATO-III cells, because 125I-EGF binding studies indicated a presence of specific binding sites for EGF on these cells ... Upon stimulation with EGF , both ODC mRNA expression and ODC enzyme activity were significantly increased in KATO-III cells ... However, unlike in other cellular systems, both EGF induced ODC mRNA expression and ODC enzyme activation were biphasic with the peaks at 15 +/- 10 min and 2.1 +/- 1.5 hrs ( mean +/- SE ) for mRNA, and 3.1 +/- 1.5 and 7.7 +/- 1.8 hrs ( mean +/- SE ) for enzyme activity, respectively
Prystowsky et al., J Invest Dermatol 1993 : However, pre-treatment with UVB significantly reduced the EGF induction of ODC
Yamamoto et al., Biol Neonate 1993 : The effects of epidermal growth factor (EGF) on ornithine decarboxylase (ODC) activity and DNA synthesis were studied during the perinatal period in rats
Zheng et al., Oncol Res 1995 : Pretreatment of Z114 cells with CAPE significantly prevented the full induction of ornithine decarboxylase (ODC) by epidermal growth factor (EGF) in a concentration- and time dependent manner ... Inhibition was observed with a concentration of CAPE as low as 1 microgram/ml, and complete inhibition of ODC induction by EGF occurred at 5 micrograms/ml. Northern analysis showed that treatment of cells with CAPE for 24 h suppressed EGF induction of ODC gene expression
Xue et al., Biochem J 1996 : In this report, 10 ( -10 ) M-10 ( -7 ) M PMA induced ODC mRNA and enzyme synthesis at 7 h, but did not significantly induce ODC activity and inhibited the EGF induction of ODC activity ... Additionally, PMA inhibited the induction of ODC by EGF through decreased EGF binding, possibly mediated by PKC activation
Ishikawa et al., Digestion 1998 (Adenocarcinoma...) : EGF induced activation of ornithine decarboxylase (ODC) was examined, because ODC is a key enzyme for the cell proliferation ... EGF induced both ODC mRNA expression and enzyme activation in a biphasic manner with the peaks at 0.5 and 3 h for mRNA and at 5 and 9 h for enzyme activity, respectively ... Indomethacin pretreatment significantly reduced EGF induced ODC activation and was completely abolished for the first 5 h ... Indomethacin suppresses and changes the response of ODC induced by EGF
Wang et al., Am J Physiol 1998 : EGF or gastrin specifically stimulates transcription of the ODC gene, whereas asparagine affects a posttranscriptional process
Milovic et al., Z Gastroenterol 1998 (Colonic Neoplasms) : ODC and SAMDC activity and putrescine uptake were strongly stimulated by EGF