Pei et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
Activation of the MAP kinase cascade by epidermal growth factor or an expression vector for a constitutively active form of the MAP kinase kinase ( MEK1 ) led to stimulation of PTTG transactivation activity
Tfelt-Hansen et al., Endocrinology 2004
(Astrocytoma...) :
Furthermore, in U87 cells PTTG expression was up-regulated by promalignant ligands epithelial growth factor (EGF) and TGFalpha, both at the protein and mRNA levels ... PTTG induction by EGF receptor (EGFR) ligands could be blocked by the specific EGFR inhibitor, AG1478 ... Although EGF stimulates HGF secretion in U87 cells, the effect of EGF on PTTG mRNA expression is independent of HGF as neutralizing antibody against HGF failed to abolish EGF induced up-regulation of PTTG mRNA