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THBD — TNF

Text-mined interactions from Literome

Murugesan et al., J Biomed Mater Res 2000 : Endothelial cells ( EC ) from human aortas, microvessels, and pulmonary arteries were examined for their expression and activity of monocyte chemotactic protein-1 (MCP-1), tissue factor, and thrombomodulin in response to tumor necrosis factor-alpha (TNFalpha) on the hydrophilic plasma polymers gamma-butyrolactone ( GBL ) and N-vinyl-2-pyrrolidone ( NVP ), along with a fibronectin ( FN ) control ... Basal expression of thrombomodulin was largely comparable for all three cell types grown on different surfaces, but TNFalpha suppressed thrombomodulin to different extents depending on the origin of the EC
Nan et al., Thromb Res 2005 : The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor ( EPCR ) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent
Dekker et al., Blood 2006 : Protein levels for thrombomodulin , endothelial nitric oxide synthase, and plasminogen activator inhibitor type-1 are altered to atheroprotective levels, even in the presence of the inflammatory cytokine TNF-alpha
Ohdama et al., Thromb Res 1991 : Pentoxifylline prevents tumor necrosis factor induced suppression of endothelial cell surface thrombomodulin
Schmidt et al., Ann Thorac Surg 2006 : Stimulation with tumor necrosis factor-alpha resulted in physiologic upregulation of tissue factor and downregulation of thrombomodulin expression
Maruyama et al., Thromb Res 1991 (Hemangioma) : These agents prevented the interleukin I (IL-I) or tumor necrosis factor (TNF) induced decrease in thrombomodulin on HUVEC
Soff et al., Blood 1991 : Expression of thrombomodulin by smooth muscle cells in culture : different effects of tumor necrosis factor and cyclic adenosine monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture
Lentz et al., Blood 1991 : Regulation of thrombomodulin by tumor necrosis factor-alpha : comparison of transcriptional and posttranscriptional mechanisms ... We conclude that TNF acts primarily to inhibit thrombomodulin transcription
Hirokawa et al., J Biochem 1990 : Previous studies have shown that thrombomodulin (TM) on endothelial cells is down-regulated by endotoxin, interleukin-1 beta (IL-1 beta), and tumor necrosis factor (TNF)
Stern et al., Diabetes Care 1991 : Tumor necrosis factor suppresses the endothelial anticoagulant cofactor thrombomodulin and induces expression of the procoagulant cofactor tissue factor
Scarpati et al., J Biol Chem 1989 : In contrast to PMA, TNF reduced thrombomodulin activity approximately 80 % with no change in thrombomodulin mRNA levels ... The different effects of PMA and TNF on thrombomodulin expression indicate that some effects of TNF are not mediated solely by protein kinase C
Conway et al., Mol Cell Biol 1988 : Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells
Herbert et al., FEBS Lett 1993 : When measured in parallel, IL-4 and IL-13 counteracted thrombomodulin down-regulation induced by LPS, IL-1 or TNF in endothelial cells
Herbert et al., Thromb Res 1993 : Endotoxin, interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) dose-dependently increased the expression of tissue factor and at the same time induced thrombomodulin down-regulation on the surface of cultured bovine aortic endothelial cells
Endo et al., Res Commun Mol Pathol Pharmacol 1995 (Disseminated Intravascular Coagulation...) : TNF-alpha is involved in the production of endothelin-1 and thrombomodulin , which play a role in the pathogenesis of DIC and whose blood levels reflect its severity
Raife et al., Blood 1996 : Thrombomodulin expression in endothelial cells is regulated by retinoic acid and tumor necrosis factor-alpha (TNF) , agents that also modulate epidermal differentiation ... We examined thrombomodulin function and regulation of thrombomodulin expression by all-trans retinoic acid ( ATRA ) and TNF in human keratinocytes and endothelial cells ... These results demonstrate that keratinocyte thrombomodulin is regulated by retinoids and Ca2+, but not by TNF , and that regulation of thrombomodulin expression differs in keratinocytes and endothelial cells
Kopp et al., Transplantation 1998 : Our aim was to express human TM cofactor activity in PAEC and to study the proinflammatory effect of tumor necrosis factor-alpha (TNF-alpha) on stable expressed human thrombomodulin in vitro