Gene interactions and pathways from curated databases and text-mining

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NFKBIZ — RELA

Text-mined interactions from Literome

Eto et al., Biochem Biophys Res Commun 2003 : Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal ( s ) in the induction of I kappa B-zeta
Muta et al., J Endotoxin Res 2003 : NF-kappaB activity is essential for the induction of IkappaB-zeta , but is not sufficient
Yamazaki et al., J Biol Chem 2005 : Therefore, IkappaB-zeta induction requires both NF-kappaB activation and stimulus-specific stabilization of its mRNA
Motoyama et al., J Biol Chem 2005 (Inflammation) : Previous studies using an NF-kappaB reporter have shown that IkappaB-zeta inhibits the activity of NF-kappaB
Totzke et al., J Biol Chem 2006 : Interestingly, IkappaB-zeta is localized in the nucleus where it aggregates in matrix associated deacetylase bodies, indicating that IkappaB-zeta regulates nuclear NF-kappaB activity rather than its nuclear translocation from the cytoplasm ... IkappaB-zeta expression itself was regulated by NF-kappaB , suggesting that its activity is controlled in a negative feedback loop
Hijioka et al., Biochem Biophys Res Commun 2007 : While the crosslinking activated NF-kappaB and induced its target gene, IkappaB-alpha, co-crosslinking of Fcgamma receptor IIB to the surface immunoglobulin complex inhibited NF-kappaB activation and the induction of IkappaB-zeta and IkappaB-alpha, suggesting critical roles for NF-kappaB in the induction
Dagvadorj et al., Innate Immun 2009 : A pharmacological inhibitor of NF-kappaB prevented LPS induced IkappaB-zeta expression, suggesting that IL-10 might inhibit LPS induced IkappaB-zeta expression via the inactivation of NF-kappaB