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NFKBIZ — RELA
Text-mined interactions from Literome
Eto et al., Biochem Biophys Res Commun 2003
:
Essential
roles for
NF-kappa B and a Toll/IL-1 receptor domain-specific signal ( s ) in the induction of
I kappa B-zeta
Muta et al., J Endotoxin Res 2003
:
NF-kappaB activity is
essential for the induction of
IkappaB-zeta , but is not sufficient
Yamazaki et al., J Biol Chem 2005
:
Therefore,
IkappaB-zeta induction
requires both
NF-kappaB activation and stimulus-specific stabilization of its mRNA
Motoyama et al., J Biol Chem 2005
(Inflammation) :
Previous studies using an NF-kappaB reporter have shown that
IkappaB-zeta inhibits the activity of
NF-kappaB
Totzke et al., J Biol Chem 2006
:
Interestingly, IkappaB-zeta is localized in the nucleus where it aggregates in matrix associated deacetylase bodies, indicating that
IkappaB-zeta regulates nuclear
NF-kappaB activity rather than its nuclear translocation from the cytoplasm ...
IkappaB-zeta expression itself was
regulated by
NF-kappaB , suggesting that its activity is controlled in a negative feedback loop
Hijioka et al., Biochem Biophys Res Commun 2007
:
While the crosslinking activated NF-kappaB and induced its target gene, IkappaB-alpha, co-crosslinking of Fcgamma receptor IIB to the surface immunoglobulin complex inhibited
NF-kappaB activation and the
induction of
IkappaB-zeta and IkappaB-alpha, suggesting critical roles for NF-kappaB in the induction
Dagvadorj et al., Innate Immun 2009
:
A pharmacological inhibitor of
NF-kappaB prevented LPS induced
IkappaB-zeta expression, suggesting that IL-10 might inhibit LPS induced IkappaB-zeta expression via the inactivation of NF-kappaB