Gene interactions and pathways from curated databases and text-mining

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IFNG — STAT4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Zhang et al., J Immunol 2000 : We and others have demonstrated that the Stat4 is critical for IFN-gamma production by activated T cells and Th1 cells
Cai et al., J Immunol 2000 (Genetic Predisposition to Disease...) : However, other signaling pathways can be used to bypass STAT4 dependent production of IFN-gamma and enhance innate resistance to T. gondii
Gollob et al., J Immunol 2000 (Immunologic Deficiency Syndromes...) : These findings demonstrate that the activation of STAT4 alone is not sufficient for IL-12 induced IFN-gamma production and proliferation and suggest that other STATs play a role in these responses to IL-12
Lawless et al., J Immunol 2000 : Since the precise role of Stat4 in IFN-gamma induction has not been established, experiments were conducted to examine Stat4 activation of IFN-gamma and other genes required for cytokine induced expression of IFN-gamma
Schindler et al., J Immunol 2001 : The production of IFN-gamma by IL-12/IL-18 activated macrophages requires STAT4 signaling and is inhibited by IL-4
Fukao et al., J Immunol 2001 : The Th2 cytokines IL-4 and IL-10 suppress Stat4 induction in DC and macrophages when present during maturation and activation, respectively, diminishing IFN-gamma production
Nakahira et al., J Immunol 2001 : An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex
Bao et al., J Immunol 2002 (Diabetes Mellitus, Type 1...) : We then examined whether the change in IL-12 induced IFN-gamma production by treatment with sex hormones was due to the regulation of STAT4 activation
Morinobu et al., Proc Natl Acad Sci U S A 2002 : We demonstrated that expression of wild-type STAT4 , but not the S721A mutant, restored normal T ( H ) 1 differentiation and IFN-gamma synthesis
Nguyen et al., Science 2002 (Arenaviridae Infections) : Here we show that IFN-alpha/beta activate STAT4 directly ( STAT, signal transducers and activators of transcription ) and that this is required for IFN-gamma production during viral infections of mice, in concert with T cell receptor derived signals
Nguyen et al., J Immunol 2002 (Herpesviridae Infections) : IL-12/STAT4 was critical for NK cell IFN-gamma expression, whereas IFN-alphabeta/STAT1 were required for induction of cytotoxicity
Hoey et al., EMBO J 2003 : However, Stat4alpha is required for normal levels of IL-12 induced interferon-gamma production from Th1 cells
Wang et al., J Clin Invest 2003 (Central Nervous System Neoplasms...) : An immune response also induced in the brain of the GIFN/STAT2-/- mice was associated with IFN-gamma gene expression by CD3+ T cells and the activation of the STAT1, STAT3, STAT4 , and STAT5 molecules
Park et al., Int Immunol 2004 : A mechanism underlying STAT4 mediated up-regulation of IFN-gamma induction inTCR triggered T cells
Mattner et al., J Immunol 2004 (Disease Progression...) : The IFN-beta induced increase of IFN-gamma production was dependent on STAT4
Berenson et al., Eur J Immunol 2004 : In summary, these results suggest that in contrast to IL-12, IFN-alphaA does not play a functionally significant role in meditating the STAT4 dependent induction of Th1 development or IFN-gamma production in CD4+ T cells
Rodriguez-Galán et al., J Immunol 2005 : The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on IFN-gamma and IL-13 expression is dependent on Stat4 and NF-kappaB but independent of Stat6, T-bet, or NFAT
Robertson et al., Blood 2005 (Lymphoma) : Impaired interferon-gamma production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma
Suto et al., J Immunol 2005 : These results indicate that PDCs preferentially produce IFN-gamma upon IL-4 stimulation by Stat6- and Stat4 dependent mechanisms
Shin et al., J Immunol 2005 (Asthma) : STAT4 , which plays a pivotal role in Th1 immune responses, enhances IFN-gamma transcription in response to the interaction of IL-12 with the IL-12R
Frisancho-Kiss et al., Brain Res 2006 (Coxsackievirus Infections...) : We have previously reported that IL-12Rbeta1 signaling increases CVB3 induced myocarditis and IL-1beta/IL-18 levels in males, while IL-12 ( p35 ) /STAT4 induced IFN-gamma does not alter the severity of acute disease
Berenson et al., J Immunol 2006 : However, in differentiated Th1 cells, IFN-alpha can induce transient, but not sustained, STAT4 phosphorylation and, in synergy with IL-18, can induce transient, but not sustained, IFN-gamma production in Th1 cells, in contrast to the sustained actions of IL-12
Karpuzoglu et al., Endocrinology 2009 : The activation of STAT4beta was mediated by IL-12 and not IFNgamma because deliberate addition or neutralization of IL-12, but not IFNgamma , affected the activation of STAT4beta
Kang et al., J Ethnopharmacol 2009 : STAT4 , but not T-bet, was involved in the upregulation of IFN-gamma by SSHT while the increased IL-4 expression was accompanied by a parallel increase in c-Maf but independent of STAT6 and GATA-3
Rottinghaus et al., Immunology 2009 : Furthermore, we demonstrate that IL-12 induced STAT-4 activation was required for T helper type 1 ( Th1 ) cytokine induced IFN-gamma production in CD8 T cells
Kim et al., Exp Mol Med 2010 (Asthma...) : Moreover, AHR, non-eosinophilic inflammation, and IFN-gamma expression were impaired in allergen challenged IL-12Rbeta2- and STAT4-deficient mice ; however, AHR and non-eosinophilic inflammation were not impaired in allergen challenged IL-4Ralpha-deficient mice, and these phenomena were accompanied by the enhanced expression of IL-12 and IFN-gamma
Yamamoto et al., Mol Cell Biol 1994 : Unlike Stat1, neither IFN-alpha nor IFN-gamma activates Stat4
Barbulescu et al., J Immunol 1998 : These data suggest that both AP-1 and STAT4 are required for IL-12 dependent IFN-gamma promoter activity, whereas IL-18 causes direct activation via AP-1
Ahn et al., J Immunol 1998 : These results indicate that IL-12 has the capacity to induce/maintain STAT4 and STAT5 proteins, and that TYK2 and JAK2 activation correlate with STAT4 phosphorylation/IFN-gamma induction and STAT5 phosphorylation/cellular proliferation, respectively